Research Database: Projects

Our research group studies rare genetic defects in metabolic pathways. We are aiming at a better understanding of pathomechanisms underlying such inborn errors of metabolism. We continuously offer internships and thesis projects focused on analytical biochemistry (for example on the development of diagnostic tests) and on the characterization of metabolic diseases. Phase 2 reactions increase the water solubility of compounds and thus facilitate their excretion. This can be achieved by conjugation of a coenzyme A (coA)-activated acid for instance with an amino acid molecule.

Project management at the H-BRS

Our research group studies rare genetic defects in metabolic pathways. We are aiming at a better understanding of pathomechanisms underlying such inborn errors of metabolism (IEM). Many metabolic diseases result in early death or severe handicaps if they are not treated in an adequate manner. Early diagnosis is a prerequisite for therapeutic approaches, which may enable normal development in some of those diseases.

Project management at the H-BRS

Information and communication technologies (ICT) have become part of our everyday life and it is almost impossible to imagine life without them. Reason for that is the increasing digitalization of our world. Especially in our economic sector ICTs are one of the most driving factors for innovation and therefore strongly responsible forthe competitiveness of many companies. But ICTs not only influence our lives within economy, they also shape our society e.g. in authorities.

Project management at the H-BRS

Cities and municipalities must create the right framework conditions for road traffic so that it is compatible for everyone from an ecological, economic and social point of view. To ensure this, precise measurements of traffic volumes and a classification of road users are required.

Project management at the H-BRS

Individual variants in the DNA sequence (i.e. the linear sequence of the 4 DNA building blocks, the so-called bases) are called polymorphisms and can influence the function of genes and thus contribute to the clinical manifestation of diseases or influence their course and therapy. In addition, polymorphism patterns can be so characteristic for each individual that they also enable the forensic identification of perpetrators and victims on the basis of a DNA trace.

Project management at the H-BRS

LowGHGWatt is a joint project with the Israeli Ben-Gurion University of the Negev. It is funded within the framework of the German-Israeli Water Technology Cooperation by BMBF and MOST.

Project management at the H-BRS

TransHyDE-Sys is a system analysis project and a joint project within the lead project TransHyDE. In addition to the system analysis, there are also implementation and research projects on the topic of H2 transport in the lead project. As a cross-sectional project, the system analysis performs a special function: On the one hand, essential system knowledge for the time-dependent construction and coupling of the energy infrastructures is generated with the help of own modelling and simulation work as well as ecological analyses.

Project management at the H-BRS

In the LEITNING project, a novel battery inverter with high mass power density is being researched and field tested to provide a highly-available and modular AC grid and grid-supporting functions using advanced circuit topologies based on innovative SiC MOSFET power modules, magnetic devices and control strategies.

Project management at the H-BRS

The "Digital Twin-4-Multiphysics Lab" (DT4MP) focuses on urban digital twins (UDTs) and multiphysics twins for industry, treating both areas equally and synergistically. By integrating real-time data and advanced simulations, DT4MP enhances urban processes, infrastructures, and industrial production efficiency. Combining AI and machine learning, the lab provides services like data analysis and virtual testing for SMEs and larger companies. Founded by leading institutes, DT4MP drives digitalization research in urban and industrial contexts.

Project management at the H-BRS

Bio-chemical research is increasingly dependent on accurate computer modelling and analysis. This field of research is by its very nature highly interdisciplinary, as basic physical laws must be implemented algorithmically in order to make relevant contributions in life science applications. The project and the associated initiative UMMBAS bundles the strong cross-disciplinary expertise at the H-BRS in method development, visualisation and the application of computer-based procedures for deciphering material science and biochemical issues.

Project management at the H-BRS