Amino acid N-Acyltransferases in Human Metabolism

Our research group studies rare genetic defects in metabolic pathways. We are aiming at a better understanding of pathomechanisms underlying such inborn errors of metabolism.
We continuously offer internships and thesis projects focused on analytical biochemistry (for example on the development of diagnostic tests) and on the characterization of metabolic diseases.

Phase 2 reactions increase the water solubility of compounds and thus facilitate their excretion. This can be achieved by conjugation of a coenzyme A (coA)-activated acid for instance with an amino acid molecule. Several enzymes may catalyze such reactions. More recently, such conjugating amino acid N-acyltransferases have attracted our attention. Our research (supported, e.g., by the Heinz und Heide Dürr Stiftung and by the Gottfried und Julia Bangerter-Rhyner-Stiftung, and by the state programs FH Basis and FH Struktur) is aiming at a better understanding of the roles of auch enzymes in health and disease.