Fynn Zahnow, Chiara Jaeger, Yassmin Mohamed, Gianluca Vogelhuber, Fabian May, Alexandra Maria Ciocan, Arianna Manieri, Stephan Maxeiner, Gabriela Krasteva-Christ, Matthew R.D. Cobain, Lars Podsiadlowski, Jose Luis Crespo-Picazo, Daniel Garcia-Parraga, Mike Althaus: The evolutionary path of the epithelial sodium channel delta-subunit in Cetartiodactyla points to a role in sodium sensing. Preprint, 2024
doi:10.1101/2024.11.18.623996 BibTeX | RIS

Alexander Perniss, Brett Boonen, Sarah Tonack, Moritz Thiel, Krupali Poharkar, Mohamad Wessam Alnouri, Maryam Keshavarz, Tamara Papadakis, Silke Wiegand, Uwe Pfeil, Katrin Richter, Mike Althaus, Johannes Oberwinkler, Burkhard Schütz, Ulrich Boehm, Stefan Offermanns, Trese Leinders-Zufall, Frank Zufall, Wolfgang Kummer: A succinate/SUCNR1-brush cell defense program in the tracheal epithelium. In: Science Advances, 9(31), eadg8842, 2023
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Rene Y. Lawong, Fabian May, Etang C. Etang, Philipp Vorrat, Jonas George, Julia Weder, Dagmar Kockler, Matthias Preller, Mike Althaus: Recording Sodium Self-Inhibition of Epithelial Sodium Channels Using Automated Electrophysiology in Xenopus Oocytes. In: Membranes, 13(5), 529, 2023
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Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius: ENaC channels. In: Zheng, Trudeau (Eds.): Properties, Function, and Pharmacology of the Superfamilies. Textbook of Ion Channels, Vol 2, Boca Raton: CRC Press, 2023, S. 323-336
doi:10.1201/9781003096276-21 BibTeX | RIS

Stephan Maxeiner, Gabriela Krasteva-Christ, Mike Althaus: Pitfalls of using sequence databases for heterologous expression studies - a technical review. In: The Journal of Physiology, 601(9), 2023, S. 1611-1623
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JinHeng Lin, Sean M. Gettings, Khaoula Talbi, Rainer Schreiber, Michael J. Taggart, Matthias Preller, Karl Kunzelmann, Mike Althaus, Michael A. Gray: Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels. In: Pflügers Archiv: European Journal of Physiology, 475(2), 2023, S. 167-179
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Catriona M. H. Anderson, Noel Edwards, Andrew K. Watson, Mike Althaus, David T. Thwaites: Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB0,+) Selectively Reduces Access for Cationic Amino Acids and Derivatives. In: Biomolecules, 12(10), 1404, 2022
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Mike Althaus, Rene Yufenyuy Lawong: Proteolytic ENaC activation in health and disease—a complicated puzzle. In: Pflügers Archiv: European Journal of Physiology, 474(2), 2022, S. 177-179
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Zeshan P. Sheikh, Matthias Wulf, Søren Friis, Mike Althaus, Timothy Lynagh, Stephan A. Pless: The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs. In: The Journal of General Physiology, 153(10), e202112899, 2021
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Sean M. Gettings, Stephan Maxeiner, Maria Tzika, Matthew R. D. Cobain, Irina Ruf, Fritz Benseler, Nils Brose, Gabriela Krasteva-Christ, Greetje Vande Velde, Matthias Schönberger, Mike Althaus: Two Functional Epithelial Sodium Channel Isoforms Are Present in Rodents despite Pronounced Evolutionary Pseudogenization and Exon Fusion. In: Molecular Biology and Evolution, 38(12), 2021, S. 5704-5725
PDF Download (CC BY 4.0) doi:10.1093/molbev/msab271 PMID urn:nbn:de:hbz:1044-opus-58483 BibTeX | RIS

Iram J. Haq, Mike Althaus, Aaron Ions Gardner, Hui Ying Yeoh, Urjita Joshi, Vinciane Saint-Criq, Bernard Verdon, Jennifer Townshend, Christopher O'Brien, Mahfud Ben-Hamida, Matthew Thomas, Stephen Bourke, Peter van der Sluijs, Ineke Braakman, Chris Ward, Michael A. Gray, Malcolm Brodlie: Clinical and molecular characterization of the R751L-CFTR mutation. In: American Journal of Physiology: Lung Cellular and Molecular Physiology, 320(2), 2021, S. L288-L300
PDF Download (CC BY 4.0) doi:10.1152/ajplung.00137.2020 PMID urn:nbn:de:hbz:1044-opus-52631 BibTeX | RIS

Lukas Wichmann, Mike Althaus: Evolution of epithelial sodium channels: current concepts and hypotheses. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 319(4), 2020, S. R387-R400
doi:10.1152/ajpregu.00144.2020 PMID BibTeX | RIS

Honglin Feng, Noel Edwards, Catriona M. H. Anderson, Mike Althaus, Rebecca P. Duncan, Yu-Ching Hsu, Charles W. Luetje, Daniel R. G. Price, Alex C. C. Wilson, David T. Thwaites: Trading amino acids at the aphid-Buchnera symbiotic interface. In: Proceedings of the National Academy of Sciences of the United States of America, 116(32), 2019, S. 16003-16011
doi:10.1073/pnas.1906223116 PMID BibTeX | RIS

Lukas Wichmann, Jasdip Singh Dulai, Jon Marles-Wright, Stephan Maxeiner, Pawel Piotr Szczesniak, Ivan Manzini, Mike Althaus: An extracellular acidic cleft confers profound H+-sensitivity to epithelial sodium channels containing the δ-subunit in Xenopus laevispH-sensitivity of Xenopus δ-ENaC. In: The Journal of Biological Chemistry, 294(33), 2019, S. 12507-12520
doi:10.1074/jbc.RA119.008255 PMID BibTeX | RIS

Monika I. Hollenhorst, Innokentij Jurastow, Rajender Nandigama, Silke Appenzeller, Lei Li, Joerg Vogel, Stephanie Wiederhold, Mike Althaus, Martin Empting, Janine Altmueller, Anna K. H. Hirsch, Veit Flockerzi, Brendan J. Canning, Antoine-Emmanuel Saliba, Gabriela Krasteva-Christ: Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling. In: The FASEB Journal, 34(1), 2019, S. 316-332
doi:10.1096/fj.201901314RR PMID BibTeX | RIS

Chrissy Kandel, Patricia Schmidt, Alexander Perniss, Maryam Keshavarz, Paul Scholz, Sabrina Osterloh, Mike Althaus, Wolfgang Kummer, Klaus Deckmann: ENaC in Cholinergic Brush Cells. In: Frontiers in Cell and Developmental Biology, Vol.6, 89, 2018
doi:10.3389/fcell.2018.00089 PMID BibTeX | RIS

Cassie R. Bakshani, Ana L. Morales-Garcia, Mike Althaus, Matthew D. Wilcox, Jeffrey P. Pearson, John C. Bythell, J. Grant Burgess: Evolutionary conservation of the antimicrobial function of mucus: a first defence against infection. In: npj Biofilms and Microbiomes, Vol.4, 14, 2018
doi:10.1038/s41522-018-0057-2 PMID BibTeX | RIS

Lukas Wichmann, Kirsty Sophia Vowinkel, Alexander Perniss, Ivan Manzini, Mike Althaus: Incorporation of the -subunit into the epithelial sodium channel (ENaC) generates protease-resistant ENaCs in Xenopus laevis. In: The Journal of Biological Chemistry, 293(18), 2018, S. 6647-6658
doi:10.1074/jbc.RA118.002543 PMID BibTeX | RIS

Anna Zakrzewicz, Katrin Richter, Alisa Agne, Sigrid Wilker, Kathrin Siebers, Bijan Fink, Gabriela Krasteva-Christ, Mike Althaus, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, Veronika Grau: Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1 beta via Different Combinations of Nicotinic Acetylcholine Receptor Subunits alpha 7, alpha 9 and alpha 10. In: Frontiers in Cellular Neuroscience, Vol.11, 189, 2017
doi:10.3389/fncel.2017.00189 PMID BibTeX | RIS

Alexander Perniss, Kathrin Preiss, Marcel Nier, Mike Althaus: Hydrogen sulfide stimulates CFTR in Xenopus oocytes by activation of the cAMP/PKA signalling axis. In: Scientific Reports, Vol.7, 3517, 2017
doi:10.1038/s41598-017-03742-5 PMID BibTeX | RIS

Maryam Keshavarz, Heike Schwarz, Petra Hartmann, Silke Wiegand, Melanie Skill, Mike Althaus, Wolfgang Kummer, Gabriela Krasteva-Christ: Caveolin-1: Functional Insights into Its Role in Muscarine- and Serotonin-Induced Smooth Muscle Constriction in Murine Airways. In: Frontiers in Physiology, Vol.8, 295, 2017
doi:10.3389/fphys.2017.00295 PMID BibTeX | RIS

Nicole C. Krause, Hanna S. Kutsche, Fabrizio Santangelo, Eric R. DeLeon, Nikolaus P. Dittrich, Kenneth R. Olson, Mike Althaus: Hydrogen sulfide contributes to hypoxic inhibition of airway transepithelial sodium absorption. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 311(3), 2016
doi:10.1152/ajpregu.00177.2016 PMID BibTeX | RIS

K. Richter, V. Mathes, M. Fronius, M. Althaus, A. Hecker, G. Krasteva-Christ, W. Padberg, A. J. Hone, J. M. McIntosh, A. Zakrzewicz, V. Grau: Phosphocholine - an agonist of metabotropic but not of ionotropic functions of α9-containing nicotinic acetylcholine receptors. In: Scientific Reports, Vol.6, 28660, 2016
doi:10.1038/srep28660 PMID BibTeX | RIS

Ervice Pouokam, Mike Althaus: Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide. In: Oxidative Medicine and Cellular Longevity, Vol.2016, 4723416, 2016
doi:10.1155/2016/4723416 PMID BibTeX | RIS

Alexander Perniss, Annemarie Wolf, Lukas Wichmann, Matthias Schoenberger, Mike Althaus: Evans Blue is not a suitable inhibitor of the epithelial sodium channel δ-subunit. In: Biochemical and Biophysical Research Communications, 466(3), 2015, S. 468-474
doi:10.1016/j.bbrc.2015.09.052 PMID BibTeX | RIS

Alisa M. Agne, Jan-Peter Baldin, Audra R. Benjamin, Maria C. Orogo-Wenn, Lukas Wichmann, Kenneth R. Olson, Dafydd V. Walters, Mike Althaus: Hydrogen sulfide decreases β-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 308(7), 2015, S. R636-R649
doi:10.1152/ajpregu.00489.2014 PMID BibTeX | RIS

Matthias Schoenberger, Mike Althaus, Martin Fronius, Wolfgang Clauss, Dirk Trauner: Controlling epithelial sodium channels with light using photoswitchable amilorides. In: Nature Chemistry, 6(8), 2014, S. 712-719
doi:10.1038/nchem.2004 PMID BibTeX | RIS

Alexandra Erb, Mike Althaus: Actions of Hydrogen Sulfide on Sodium Transport Processes across Native Distal Lung Epithelia (Xenopus laevis). In: PLoS ONE, 9(6), e100971, 2014
doi:10.1371/journal.pone.0100971 PMID BibTeX | RIS

Klaus Deckmann, Katharina Filipski, Gabriela Krasteva-Christ, Martin Fronius, Mike Althaus, Amir Rafiq, Tamara Papadakis, Liane Renno, Innokentij Jurastow, Lars Wessels, Miriam Wolff, Burkhard Schuetz, Eberhard Weihe, Vladimir Chubanov, Thomas Gudermann, Jochen Klein, Thomas Bschleipfer, Wolfgang Kummer: Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes. In: Proceedings of the National Academy of Sciences of the United States of America, 111(22), 2014, S. 8287-8292
doi:10.1073/pnas.1402436111 PMID BibTeX | RIS

Anna Bell, Mike Althaus, Martin Diener: Communication between mast cells and rat submucosal neurons. In: Pflügers Archiv: European Journal of Physiology, 467(8), 2014, S. 1809-1823
doi:10.1007/s00424-014-1609-9 PMID BibTeX | RIS

Matthias Schoenberger, Mike Althaus: Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation. In: Expert Opinion on Therapeutic Patents, 23(10), 2013, S. 1383-1389
doi:10.1517/13543776.2013.829454 PMID BibTeX | RIS

Mike Althaus, Wolfgang G. Clauss: Gasotransmitters: novel regulators of ion channels and transporters. In: Frontiers in Physiology, Vol.4, 27, 2013
doi:10.3389/fphys.2013.00027 PMID BibTeX | RIS

Mike Althaus: ENaC inhibitors and airway re-hydration in cystic fibrosis: state of the art. In: Current Molecular Pharmacology, 6(1), 2013, S. 3-12
doi:10.2174/18744672112059990025 PMID BibTeX | RIS

Patrick Krumm, Teresa Giraldez, Diego Alvarez de la Rosa, Wolfgang G. Clauss, Martin Fronius, Mike Althaus: Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC). In: Bioorganic & Medicinal Chemistry, 20(13), 2012, S. 3979-3984
doi:10.1016/j.bmc.2012.05.021 PMID BibTeX | RIS

Martin Fronius, Wolfgang G. Clauss, Mike Althaus: Why do we have to move fluid to be able to breathe?. In: Frontiers in Physiology, Vol.3, 146, 2012
doi:10.3389/fphys.2012.00146 PMID BibTeX | RIS

Mike Althaus: Gasotransmitters: novel regulators of epithelial Na+ transport?. In: Frontiers in Physiology, Vol.3, 83, 2012
doi:10.3389/fphys.2012.00083 PMID BibTeX | RIS

Diana Wesch, Mike Althaus, Pablo Miranda, Ignacio Cruz-Muros, Martin Fronius, Tomas Gonzalez-Hernandez, Wolfgang G. Clauss, Diego Alvarez de la Rosa, Teresa Giraldez: Differential N termini in epithelial Na+ channel δ-subunit isoforms modulate channel trafficking to the membrane. In: American Journal of Physiology: Cell physiology, 302(6), 2012
doi:10.1152/ajpcell.00255.2011 PMID BibTeX | RIS

M. Althaus, K. D. Urness, W. G. Clauss, D. L. Baines, M. Fronius: The gasotransmitter hydrogen sulphide decreases Na⁺ transport across pulmonary epithelial cells. In: British Journal of Pharmacology, 166(6), 2012, S. 1946-1963
doi:10.1111/j.1476-5381.2012.01909.x PMID BibTeX | RIS

Mike Althaus, Alexandra Pichl, Wolfgang G. Clauss, Werner Seeger, Martin Fronius, Rory E. Morty: Nitric Oxide Inhibits Highly Selective Sodium Channels and the Na+/K+-ATPase in H441 Cells. In: American Journal of Respiratory Cell and Molecular Biology, 44(1), 2011, S. 53-65
doi:10.1165/2009-0335OC PMID BibTeX | RIS

Mike Althaus, Wolfgang G. Clauss, Martin Fronius: Amiloride-sensitive sodium channels and pulmonary edema. In: Pulmonary Medicine, Vol.2011, 830320, 2011
doi:10.1155/2011/830320 PMID BibTeX | RIS

Diana Wesch, Pablo Miranda, Domingo Afonso-Oramas, Mike Althaus, Javier Castro-Hernandez, Jaime Dominguez, Rory E. Morty, Wolfgang Clauss, Tomas Gonzalez-Hernandez, Diego Alvarez de la Rosa, Teresa Giraldez: The neuronal-specific SGK1.1 kinase regulates δ-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling. In: American Journal of Physiology: Cell physiology, 299(4), 2010, S. C779-C790
doi:10.1152/ajpcell.00184.2010 PMID BibTeX | RIS

Martin Fronius, Roman Bogdan, Mike Althaus, Rory E. Morty, Wolfgang G. Clauss: Epithelial Na+ channels derived from human lung are activated by shear force. In: Respiratory Physiology & Neurobiology, 170(1), 2010, S. 113-119
doi:10.1016/j.resp.2009.11.004 PMID BibTeX | RIS

Mike Althaus, Martin Fronius, Yasmin Buchaeckert, Istvan Vadasz, Wolfgang G. Clauss, Werner Seeger, Roberto Motterlini, Rory E. Morty: Carbon Monoxide Rapidly Impairs Alveolar Fluid Clearance by Inhibiting Epithelial Sodium Channels. In: American Journal of Respiratory Cell and Molecular Biology, 41(6), 2009, S. 639-650
doi:10.1165/rcmb.2008-0458OC PMID BibTeX | RIS

Mike Althaus, Roman Bogdan, Wolfgang G. Clauss, Martin Fronius: Mechano-sensitivity of epithelial sodium channels (ENaCs): laminar shear stress increases ion channel open probability. In: The FASEB Journal, 21(10), 2007, S. 2389-2399
doi:10.1096/fj.06-7694com PMID BibTeX | RIS