Department of Natural Sciences

130925_hbrs_illges_09.jpg (DE)

Prof. Dr Harald Illges

Professor for Immunology and Cell Biology

harald.illges@h-brs.de

Unit

Department of Natural Sciences

Location

Rheinbach

Room

A 218

Address

von-Liebig-Str. 20

53359, Rheinbach

Telephone

+49 2241 865 570

Profile

Lectures and courses

BSc Biology

MSc Biology

Fields of research
  • Autoimmunity
  • Immunodeficiency
  • Complement System

  • Neuro-immunology

Fields of cooperation
  • Immunological diseases
  • Models for inflammatory reactions

  • Molecular biology of the immune system

  • EU Networks AUTOROME and EURORA
Additional functions (self-administration)
  • Authorized representative for the organisation of the degree programme Biology

Curriculum vitae

Personal Background
  • Study of Biology at University in Cologne
  • Postdoctoral fellow (DFG scholarship) at University of Alabama, Birmingham, USA
  • Member of research staff at University Hospital Freiburg
  • Group leader at University Konstanz
  • State doctorate (habilitation) at University Konstanz in the field of immunology
  • Formation and leadership of Biotechnologal Institute Thrugau, Switzerland
  • Professor for Immunology and Cell Biology at University of Applied Sciences Bonn-Rhein-Sieg

Publications

Publications (since 2000)
  • Illges H., Braun M., Peter H.H. and I. Melchers. 2000. Reduced expression of the complement receptor type 2 (CR2, CD21) by synovial fluid B and T lymphocytes. Clin Exp Immunol 122:270-276.

    http://www.ncbi.nlm.nih.gov/pubmed/11091285;
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  • Denz A., Eibel H., Illges H., Kienzle G., Schlesier M. and H.H. Peter. 2000. Impaired up-regulation of CD86 in B cells of "type A" common variable immunodeficiency patients.Eur J Immunol 30:1069-1077.
    http://www.ncbi.nlm.nih.gov/pubmed/10760795
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  • Allam A. and H. Illges. 2000. Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells. Immunobiology 202:353-362.

    http://www.ncbi.nlm.nih.gov/pubmed/11131152

  • Schwab J. and H. Illges. 2001. Regulation of CD21 expression by DNA methylation and histone deacetylation. Int Immunol 13:705-710.

    http://www.ncbi.nlm.nih.gov/pubmed/11312258
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  • Schwab J. and H. Illges. 2001. Silencing of CD21 expression in synovial lymphocytes is independent of methylation of the CD21 promoter CpG island. Rheumatol Int 20:133-137.

    http://www.ncbi.nlm.nih.gov/pubmed/11411956

  • Solomon S., Masilamani M., Rajendran L., Bastmeyer M., Stuermer C.A. and H. Illges. 2002. The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs. Immunobiology 205:108-119.
    http://www.ncbi.nlm.nih.gov/pubmed/11999340 
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  • Solomon S., Kolb C., Mohanty S., Jeisy-Walder E., Preyer, R. Schollhorn V. and H. Illges. 2002. Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35). Eur J Immunol 32:644-651.
    http://www.ncbi.nlm.nih.gov/pubmed/11857338
    Free Artikel
  • Mierau R. and H. Illges. 2002. Autoantibodies and the complement system--significance for pathogenesis of rheumatoid arthritis?. Z Rheumatol 61:460-463.

    http://www.ncbi.nlm.nih.gov/pubmed/12426853

  • Masilamani M., von Seydlitz E., Bastmeyer M. and H. Illges. 2002. T cell activation induced by cross-linking CD3 and CD28 leads to silencing of Epstein-Barr virus/C3d receptor (CR2/CD21) gene and protein expression. Immunobiology 206:528-536.
    http://www.ncbi.nlm.nih.gov/pubmed/12607728
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  • Illges, H. 2002. Die Rolle der Komplementpfade, Fc-Rezeptoren und Antikörper in einem Rheumamodell. Immunologie Aktuell 2:179-181.
  • Rajendran L., Masilamani M., Solomon S., Tikkanen R., Stuermer C.A., Plattner H. and H. Illges. 2003. Asymmetric localization of flotillins/reggies in preassembled platforms confers inherent polarity to hematopoietic cells. Proc Natl Acad Sci U S A 100:8241-8246.

    http://www.ncbi.nlm.nih.gov/pubmed/12826615
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  • Mohanty S., Weiner S.M., Mentele R., Vaith P., Lottspeich F. and H. Illges. 2003. Human IgG1/IgG3 cryoglobulin suggesting lack of allelic exclusion. Mol Immunol 39:1003-1011.
    http://www.ncbi.nlm.nih.gov/pubmed/12749907
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  • Deininger S.O., Rajendran L., Lottspeich F., Przybylski M., Illges H., Stuermer C.A. and A. Reuter. 2003. Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons. Mol Cell Neurosci 22:544-554.
    http://www.ncbi.nlm.nih.gov/pubmed/12727449
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  • Wehr C., Eibel H., Masilamani M., Illges H., Schlesier M., Peter H.H. and K. Warnatz. 2004. A new CD21low B cell population in the peripheral blood of patients with SLE. Clin Immunol. 113(2):161-71.
    http://www.ncbi.nlm.nih.gov/pubmed/15451473
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  • Solomon S., Masilamani M., Mohanty S., Schwab J.E., Boneberg E.M., and H. Illges. 2004. Generation of three-dimensional pannus-like tissues in vitro from single cell suspensions of synovial fluid cells from arthritis patients. Rheumatol Int 24:71-76.
    http://www.ncbi.nlm.nih.gov/pubmed/12811506
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  • Masilamani M., von Kempis J. and H. Illges. 2004. Decreased levels of serum soluble complement receptor-II (CR2/CD21) in patients with rheumatoid arthritis. Rheumatology (Oxford) 43:186-190.

    http://www.ncbi.nlm.nih.gov/pubmed/12867574
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  • Masilamani M., Nowack R., Witte T., Schlesier M., Warnatz K., Glocker M.O., Peter H.H. and H. Illges. 2004. Reduction of Soluble Complement Receptor II/CD21 in Systemic Lupus Erythomatosus and Sjoegren´s Syndrome but not Juvenile Arthritis. Scand J Immunol 60(6):625-30.
    http://www.ncbi.nlm.nih.gov/pubmed/15584974
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  • Klett V., Boneberg E.M., Trenz K., Knippers R. and H. Illges. 2004. Hydrostatic pressure induces apoptosis in the human leukemic T cell line Jurkat via the mitochondrial pathway. Scand J Immunol 60(4):403-11.
    http://www.ncbi.nlm.nih.gov/pubmed/15379865
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  • Hu, H., Illges H., Gruss C. and R. Knippers. 2005. Distribution of the chromatin-protein DEK on an active and inactive CD21/CR2 gene in two B lymphocyte cell lines. Int Immunol 17(6):789-96.

    http://www.ncbi.nlm.nih.gov/pubmed/15908448
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  • Solomon S., Kassahn D. and H. Illges. 2005. The role of the complement and the FcγR system in the pathogenesis of arthritis. Arthritis Rheum Therapy 7(4):129-35.

    http://www.ncbi.nlm.nih.gov/pubmed/15987494
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  • Möller S., Mix E., Blüggel M., Serrano-Fernández P., Koczan D., Kotsikoris V, Kunz M, Watson M, Pahnke J., Illges H., Kreutzer M., Mikkat S., Thiesen H.J., Glocker M.O., Zettl U.K. and Ibrahim S.M.. 2005. Collection of soluble variants of membrane proteins for transcriptomics and proteomics. In Silico Biology 5, 0028.

    http://www.ncbi.nlm.nih.gov/pubmed/15984938
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  • Spohn, G., Schwarz K. , Maurer P., Illges H., Rajasekaran N., Choi Y. , Jennings G.T. and M.F. Bachmann. 2005. Protection against osteoporosis by active immunization with TRANCE/RANKL displayed on virus-like particles. J Immunol, 175 (9) 6211-8.

    http://www.ncbi.nlm.nih.gov/pubmed/16237119
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  • S. Solomon, Rajasekaran N., Jeisy-Walder E., Snapper S. B.  and H. Illges. 2005. A crucial role for macrophages in the pathology of K/BxN sera induced arthritis. Eur J Immunol, 7 (4) 129-35.
    http://www.ncbi.nlm.nih.gov/pubmed/16180250
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  • Boneberg E.M., von Seydlitz E., Propster K., Watzl H., Rockstroh B. and H. Illges. 2006. D3 dopamine receptor mRNA is elevated in T cells of schizophrenic patients whereas D4 dopamine receptor mRNA is reduced in CD4(+)-T cells. J Neuroimmunol 173:180-187.
    http://www.ncbi.nlm.nih.gov/pubmed/16376996
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  • Kneilling M., Hültner L., Pichler B., Mailhammer R., Morawietz L., Solomon S., Eichner M., Sabatino, J., Biedermann T., Krenn V.,Weber V.A., Illges H., Haubner R, and M. Röcken. 2007. Targeted Mast Cell-Silencing silencing protects against joint destruction and angiogenesis in experimental arthritis in mice. Arthritis Rheum 56:1806-1816.

    http://www.ncbi.nlm.nih.gov/pubmed/17530709
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  • Singh A., Blank M., Shoenfeld Y., and H. Illges. 2008. Antiphospholipid syndrome patients display reduced titers of soluble CD21 in their sera irrespective of circulating anti-beta-2-glycoprotein-I autoantibodies. Rheumatol Int. 2008 May;28(7):661-5.
    http://www.ncbi.nlm.nih.gov/pubmed/18172655
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  • Hoefer M.M., Aichem A., Knight, A.M. and H. Illges. 2008. Modulation of murine complement receptor type 2 (CR2/CD21) ectodomain shedding by its cytoplasmic domain. Mol Immunol. 2008 Apr;45(8):2127-37.
    http://www.ncbi.nlm.nih.gov/pubmed/18295335
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  • Masilamani, M., Rajasekaran N., Singh A., Low H., Albus K., Anders S., Behne F., Eiermann P., König K., Mindnich C., Ribarska T.P., and H. Illges. 2008. Systemic reduction of soluble complement receptor II/CD21 during pregnancy to levels reminiscent of autoimmune disease. Rheumatol Int. 2008 Sep;28(11):1137-41.
    http://www.ncbi.nlm.nih.gov/pubmed/18500464
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  • Kienbaum M., Koy C., Montgomery H.V., Drynda H., Lorenz P., Illges H., Tanaka K., Kekow J., Guthke R., Thiesen H.-J., and M.O. Glocker. 2009. Mass Spectrometric Characterization of Apheresis Samples from Rheumatoid Arthritis Patients leads to Knowledge-based Considerations for Improvements of Plasmapheresis Therapy. Proteomics Clin. Appl. 2009, 3, 1-14.
    http://www.ncbi.nlm.nih.gov/pubmed/21136988
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  • Boneberg E.M., Illges H., Legler D.F., Fürstenberger G. 2009. Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvascular Research, 2009 Dec;78(3):325-31. Epub 2009 Jul 15.
    http://www.ncbi.nlm.nih.gov/pubmed/19615385
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  • Rajasekaran N., Solomon S., Gajda M., Ohtsu H., Watanabe T., Bräuer R.  and H. Illges. 2009. Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis. Int Immunol. 2009 Nov; 21(11):1263-8

    http://www.ncbi.nlm.nih.gov/pubmed/19762454
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  • Rajendran L., Beckmann J., Magenau A., Boneberg E.M., Gaus K., Viola A., Giebel B. and H. Illges. 2009. Flotillins are involved in the polarization of primitive and mature hematopoietic cells. PLOS 2009 Dec 22;4(12):e8290.

    http://www.ncbi.nlm.nih.gov/pubmed/20027317
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  • Singh A., Vastert S. J., Prakken B. J. and H. Illges. 2011. Decreased levels of sCD21 and sCD23 in blood of patients with Systemic-Juvenile Arthritis, Polyarticular-Juvenile Arthritis and Pauciarticular-Juvenile Arthritis. Rheumatol Int. 2011 Feb 17. [Epub ahead of print]
    http://www.ncbi.nlm.nih.gov/pubmed/21328056
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  • Frommholz, D., Krämer M., Raffelsieper M. and H. Illges. 2011. Kriminaltechnische Methoden zur Aufklärung von Schussdelikten. Biospektrum in press, DOI;: 10.1007/s12268-011

    http://www.springerlink.com/content/kp2474550463412u/?MUD=MP

  • Denninger L., Rasmussen S., Larsen J.M.  , Ørskov C., Poulsen S., Jensen L., Sørensen P., Christensen J.P., Illges H., Ødum N.  and T. Labuda . 2011.
    JNK1 but not JNK2 is required in two mechanistically distinct models of inflammatory arthritis. Am J Pathol. 2011 Oct;179(4):1884-93. Epub 2011 Aug 11
    http://www.ncbi.nlm.nih.gov/pubmed/21839715
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  • Thiel J., Kimmig L., Salzer U., Grudzien M., Lebrecht D., Hagena T., Draeger R., Völxen N., Bergbreiter A., Jennings S., Gutenberger S., Aichem A., Illges H., Hannan J.P., Kienzler A.-K., Rizzi M., Eibel H., Peter H.-H., Warnatz K., Grimbacher B, Rump J.-A., Schlesier M. 2011. Genetic CD21 deficiency is associated with hypogammaglobulinemia. J Allergy Clin Immunol. 2011 Oct 27
    http://www.ncbi.nlm.nih.gov/pubmed/22035880
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  • Frommholz, D., Illges, H.2012. Maximal locomotor depression follows maximal ankle swelling during the progression of arthritis in K/BxN mice. Rheumatol Int in press, DOI 10.1007/s00296-011-2337-5

    http://www.ncbi.nlm.nih.gov/pubmed/22210276

  • Low, H.-Z. Hilbrans, D., Schmidt-Wolf, I.G.H. and H. Illges. 2012. Enhanced CD21 expression and shedding in chronic lymphatic leukemia: a possible pathomechanism in disease progression. Int J Hematol. 2012 Sep;96(3):350-6.
    http://www.ncbi.nlm.nih.gov/pubmed/22899340

  • Raffelsieper, M., Mielenz, B., Häußler, S., Sauerwein, H., Mielenz, M. and H. Illges. 2012. Production and Characterization of a Monoclonal Antibody against Bovine Adiponectin. Hybridoma (Larchmt). 2012 Dec;31(6):465-8.
    http://www.ncbi.nlm.nih.gov/pubmed/23244328

  • Singh, A., Leng, L., Fan, J., Gajda, M., Bräuer, R., Fingerle-Rowson, G., Bucala, R., Illges H. 2013. Macrophage-derived, macrophage migration inhibitory factor (MIF) is necessary to induce disease in the K/BxN serum-induced model of arthritis. Rheumatol Int. 2013 Sep;33(9):2301-8. http://www.ncbi.nlm.nih.gov/pubmed/23503937

  • Nent, E., Frommholz, D., Gajda, M., Bräuer, R., Illges H. 2013. Histamine 4 receptor plays an important role in auto-antibody-induced arthritis. Int Immunol. 2013 Jul;25(7):437-43. doi: 10.1093/intimm/dxt008. Epub 2013 Apr 1.
    http://www.ncbi.nlm.nih.gov/pubmed/23545338

  • Singh A., Rajasekaran N., Hartenstein B., Szabowski S., Gajda M., Angel P., Bräuer R., Illges H. 2013. Collagenase-3 (MMP-13) deficiency protects C57BL/6 mice from antibody-induced arthritis. Arthritis Res Ther. 2013 Dec 27;15(6):R222.

  • Rajasekaran N., Illges, H. 2014. Matrix Metaloproteinase MMP-9 promotes K/BxN sera induced arthritis in mice. Open Journal of Rheumatology and Autoimmune Diseases, Vol. 4 No. 1, 2014, pp. 22-28. doi: 10.4236/ojra.2014.41003

  • Linke, K., Illges, H. 2015. Detection of sCD21 in human blood using ELISA is influenced by Ethylenediaminetetraacetic acid (EDTA) containing blood collection tubes. Clin Lab. 2015;61(11):1803-8.

  • Opuni K.F.M., Solomon S., Metzen F., Frommholz D., Koy C., Röwer C., Glocker M.O., Illges H., and Anderson P.C. 2017. In silico Epitope Mapping of Glucose-6-Phosphate Isomerase: A Rheumatoid Arthritis Autoantigen.  J Proteomics Bioinform, 10(3) 60-72 (2017)/ ISSN: 0974-276X

  •  Yelena Yefremova, Y., Melder, F.T.I., Danquah, B.D., Opuni, K.F.M., Koy, C., Ehrens, A., Frommholz, D., Illges, H., Koelbel, K., Sobott, F., and Glocker, M.O. 2017. Apparent Activation Energies of Protein Complex Dissociation in the Gas Phase Determined by Electrospray Mass Spectrometry. Anal Bioanal Chem, in press, DOI 10.1007/s00216-017-0603-4