Institut für funktionale Gen-Analytik (IFGA)

Student Theses

Bachelor, Master and PhD theses completed at IFGA
2024
  1. Laura Hollweg. BSc Thesis. Caenorhabitis elegans as a Model Organism for 3-Hydroxy-3-Methylglutaryl Coenzyme A Lyase Deficiency in Humans. Supervisor: Prof. Jörn Oliver Sass
  2. Jiamin Huang. BSc Thesis. Genetic Deficiency of Human Aminoacylase 3.  Supervisor: Prof. Jörn Oliver Sass
  3. Nora Schwarz. BSc Thesis. Genetic deficiency of 3-hydroxyisobutyryl-coenzyme A hydrolase in Homo sapiens and Caenorhabditis elegans and its impact on mitochondrial respiration.  Supervisor: Prof. Jörn Oliver Sass
  4. Paola Paulin Koleva. BSc Thesis. 3-Hydroxyisobutyrate Dehydrogenase Deficiency in Caenorhabditis elegans.  Supervisor: Prof. Jörn Oliver Sass
  5. Chamoda Alankara. BSc Thesis. Partial Characterisation and Inhibition of Human Aminoacylase 3.  Supervisor: Prof. Jörn Oliver Sass
2023
  1. Luján López, Karen L. MSc Thesis. Characterisation of a novel mutation in the a-subunit of the human epithelial sodium channel identified in a patient with hypertension. Supervisor: Prof. Mike Althaus
  2. Etang, Etang C. MSc Thesis. Epitope tagging and functional characterization of Cavia porcellus epithelial sodium channel (ENaC) isoforms. Supervisor: Prof. Mike Althaus
  3. George, Jonas. BSc Thesis. Recording sodium self-inhibition in both abg- and dbg-ENaC orthologs using automated electrophyisology. Supervisor: Prof. Mike Althaus
  4. Jäger, Chiara. BSc Thesis. Analysis of Genes Coding for Epithelial Sodium Channel Subunits in Cetaceans.Supervisor: Prof. Mike Althaus
  5. Vogelhuber, Gianluca. BSc Thesis. Investigating Salt Taste in Cetaceans. Supervisor: Prof. Mike Althaus
  6. Zahnow, Fynn. BSc Thesis. Investigating Epithelial Sodium Channel Diversity in Terrestrial Artiodactyla: An Integrative Approach using Genomic Databases with Experimental Validation in Ovis aries. Supervisor: Prof. Mike Althaus
  7. Hollenbeck, Jana C. MSc Thesis. Ketone Body Metabolism in Retinal Müller Cells. Supervisor: Prof. Jörn Oliver Sass
  8. Hintzen, Julia. BSc Thesis. Ketone metabolism in Naegleria lovaniensis, a model organism for the “brain-eating” amoeba. Supervisor: Prof. Jörn Oliver Sass
  9. Ahmeti, Yllka. BSc Thesis. Analysis of the Activity of the SCOT Isoenzyme Encoded by the OXCT2 Gene.Supervisor: Prof. Jörn Oliver Sass
  10. Ratrianto, Betari Qalhata. BSc Thesis. A Caenorhabditis elegans Mutant as a Potential Invertebrate Animal Model for Human 3-Hydroxy-3-Methylglutaryl Coenzyme A Deficiency. Supervisor: Prof. Jörn Oliver Sass
  11. Schlimgen, Fabian. BSc Thesis. Enzyme Kinetics and Long-Term Enzyme Stability of Human Aminoacylase 3. Supervisor: Prof. Jörn Oliver Sass
  12. Oswald-Hennemann, Jana Naomi. BSc Thesis. Enzymes of ketone body metabolism in patients with 3-hydroxy-3-methylglutaryl-coenzyme A deficiency and in HepG2 cells. Supervisor: Prof. Jörn Oliver Sass
  13. Silva Faria, Claudia. BSc Thesis. Molecular Defects underlying 3-hydroxyisobutyric Aciduria in Humans and Caenorhabditis elegans. Supervisor: Prof. Jörn Oliver Sass
  14. Bruns, Annika Marie. BSc Thesis. Studies of BDH1 Sequence Variants: Searching for Deficiency of Human 3-Hydroyxy-n-Butyrate Dehydrogenase. Supervisor: Prof. Jörn Oliver Sass
2022

  1. Schulke, Daniel. Dr. rer. nat. Amino acid N-acyltransferases in Human Metabolism. Supervisors: Prof. Jörn Oliver Sass, Prof. Michael Gütschow (Universität Bonn)

  2. Arslan, Rula. MSc Thesis. An Improved Enzyme Activity Test for Aspartoacylase in Laboratory

    Diagnostics of Canavan Disease. Supervisor: Prof. Jörn Oliver Sass

  3. Enoruwa, David. MSc Thesis. Overexpression, Partial Purification and Partial Characterization of Human N-Acetyl-aspartylglutamate Synthetase II. Supervisor: Prof. Jörn Oliver Sass

  4. Sarah Heß. PhD Thesis. Optimierung von STR-Profilen aus telogenen Einzelhaaren. Supervisor: Prof Richard Jäger

  5. Fabian May. BSc Thesis. Development of an automated electrophysiology protocol to study proteolytic activation of epithelial sodium channels. Supervisor: Prof. Mike Althaus

  6. Philipp Vorrat. BSc Thesis. Development of an automated electrophysiology protocol to study sodium self-inhibition in epithelial sodium channels. Supervisor: Prof. Mike Althaus

  7. Yassmin Mohamed. MSc Thesis. Analysis of Pseudogenization of ENaC coding Genes in Marine Mammals and Potential Contribution of Delta ENaC in Sodium Taste. Supervisor: Prof. Mike Althaus

  8. Victoria Malcherek. BSc Thesis. Development of a Manual Gene Search Strategy to Search for δ-ENaC in Lungfish Species. Supervisor: Prof. Mike Althaus

  9. Rene Yufenyuy Lawong. MSc Thesis. Isoform-specific-regulation of the mammalian Epithelial sodium channel (ENaC) in the αßy- and dßy-subunit arrangements. Supervisor: Prof. Mike Althaus

  10. Rafael Adrian Vazquez Alor. MSc Thesis. Sodium homeostasis in the sea lamprey. Supervisor: Prof. Mike Althaus

2021

  1. Sara-Sophie Poethe. Bachelor Thesis. Validation of a method using Illumina Next Generation Sequencing for forensic DNA typing. Supervisor: Prof Richard Jäger
  2. Sandra Eickert. Bachelor Thesis. Identification of sequence variants of the human OXCT2 gene by Next Generation Sequencing (NGS) of DNA.  Supervisors: Prof Jörn Oliver Sass, Prof Richard Jäger
  3. Mishell Montserratt García Villamarín. Bachelor Thesis. Characterization of High and Low Biomass Environmental Samples by 16S and ITS Targeted Amplicon Sequencing. Supervisor: Prof Martin Sieber
  4. Richard Tillmann. Bachelor Thesis. Establishment of Long-Range PCR assays for Next Generation Sequencing based Analysis of Parkinson Disease related Human Solute Carrier Genes. Supervisor: Prof Richard Jäger
  5. Susanne Kurz. BSc Thesis. Glutarylation in Glutaric Aciduria Type 1. Supervisor: Prof Jörn Oliver Sass
  6. Chantal Schmitt. BSc Thesis. Exploration of Enzymes involved in Ketone Body Metabolism. Supervisor: Prof Jörn Oliver Sass

2020

  1. Jasmin Ewert. Bachelor Thesis. Establishment of a Long-Range PCR based NGS Assay for High Throughput Sequencing of the Human Parkinson’s Disease associated Transporter Genes SLC6A3 and SLC22A3.  Supervisors: Prof. Dr. Richard Jäger, Prof. Dr. Walter Witke.
  2. Arthur Cleal. Bachelor Thesis. Quantitative PCR based analysis of DNA degradation. Supervisor: Prof. Dr. Richard Jäger.
  3. Rahinat Muhammad. Bachelor Thesis. The exploration of long-range polymerase chain reaction and next-generation sequencing procedures for the detection of mutations in the MPV17 gene. Supervisors: Prof. Dr. Hans Weiher.
  4. Anna Mona Rosendahl. Bachelor Thesis. Optimization of Loci Balance for Short Tandem Repeat Analysis by Next Generation Sequencing. Supervisor: Prof. Dr. Richard Jäger.
  5. Yuleisy Lucrecia Whilby Hall. Bachelor Thesis. Development and Realisation of a Clinical Trial Regarding the Effect of Herbal Mouthwash with Antibacterial Properties for the Oral Microbiome of Healthy Subjects. Supervisor: Prof. Martin Sieber.
  6. Glenn MG Theunissen. PhD Thesis. DNA profiling of single sperm cells and single skin flakes using micromanipulation and whole genome amplification. Supervisor: Prof. Dr. Richard Jäger.
  7. Nina Wetzig. Bachelor Thesis. Taxonomiebasierte statistische Mikrobiomanalyse auf Basis von NGS Daten. Supervisor: Prof. Dr. Ralf Thiele.
  8. Sonia Aktar. MSc Thesis. Bi-allelic co-expression of selected sequence variants in the ASPA gene for the study of compound heterozygosity. Supervisor: Prof. Jörn Oliver Sass
  9. Annika Brimmers. BSc Thesis. Research on human ketone body utilization: expressing and characterizing isoforms and mutants of succinyl-coenzyme A : 3-oxoacid coenzyme A transferase. Supervisor: Prof. Jörn Oliver Sass
  10. Jana Caroline Hollenbeck. BSc Thesis. Aminoacylase 1 in Huntington disease. Supervisor: Prof. Jörn Oliver Sass
  11. Enise Kumas. BSc Thesis. Assessment of 3-hydroxy-2-methylbutyryl-coenzyme A dehydrogenase in human cells. Supervisor: Prof. Jörn Oliver Sass
  12. Viktoria Pasareva. MSc Thesis. Overexpression, Purification and Characterization of the Endoprotease Activity and Kinetics of Human Aminoacylase 3. Supervisor: Prof. Jörn Oliver Sass
  13. Imke von Stülpnagel. BSc Thesis. Partial Characterisation of recombinant human Glycine N-acyltransferase-like protein 2 and the influence of sequence variation on enzyme activity. Supervisor: Prof. Jörn Oliver Sass
  14. Tamara Wied. BSc Thesis. Compound Heterozygosity in Aspartoacylase Deficiency. Supervisor: Prof. Jörn Oliver Sass

2019

  1. Maria del Mar Boronat. Bachelor Thesis. Relationship between DNA degradation and post-mortem interval. Supervisor: Prof. Dr. Richard Jäger.
  2. Adesanoye Neville Olabode. Meta-analysis of microbiome clinical trials and microbial analysis of skin and soil samples. Supervisor: Prof Martin Sieber.
  3. Simone Janik. Bachelor Thesis. Eine statistische Analyse von Mikrobiomdaten aus dem Next Generation Sequencing. Supervisor: Prof. Dr. Ralf Thiele.
  4. Sebastian Ginzel. PhD Thesis. Enabling Versatile And Comprehensive Analysis Of Genomic Variant Data. Supervisor: Prof. Dr. Ralf Thiele.
  5. Rebecca Engler. BSc Thesis. Enzyme activity of sulfite oxidase in human cells. Supervisor: Prof. Jörn Oliver Sass
  6. Mhd Aghyad Al Kabbani. MSc Thesis. Purification and Characterization of Recombinant Human Acylpeptide Hydrolase. Supervisor: Prof. Jörn Oliver Sass
  7. Niloufar Mosaddeghzadeh. MSc Thesis. Assessment of Read-through drugs in Canavan disease. Supervisor: Prof. Jörn Oliver Sass

2018

  1. Despina Yohanna Tsortouktzidis. Characterization of Acylpeptide  hydrolase (APEH) sequence variants and their potential impact on pharmacogenetics. Supervisor: Prof. Jörn Oliver Sass

 

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Institut für funktionale Gen-Analytik