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Institute for Functional Gene Analytics (IFGA)

Student Theses

Bachelor, Master and PhD theses completed at IFGA
2023
  1. Brezina Borges, Matias. BSc Thesis. In silico studies on the role of actin flexibility in M- to C-tropomyosin transition. Supervisor; Prof. Matthias Preller
  2. Luján López, Karen L. MSc Thesis. Characterisation of a novel mutation in the a-subunit of the human epithelial sodium channel identified in a patient with hypertension. Supervisor: Prof. Mike Althaus
  3. Etang, Etang C. MSc Thesis. Epitope tagging and functional characterization of Cavia porcellus epithelial sodium channel (ENaC) isoforms. Supervisor: Prof. Mike Althaus
  4. George, Jonas. BSc Thesis. Recording sodium self-inhibition in both abg- and dbg-ENaC orthologs using automated electrophyisology. Supervisor: Prof. Mike Althaus
  5. Jäger, Chiara. BSc Thesis. Analysis of Genes Coding for Epithelial Sodium Channel Subunits in Cetaceans.Supervisor: Prof. Mike Althaus
  6. Vogelhuber, Gianluca. BSc Thesis. Investigating Salt Taste in Cetaceans. Supervisor: Prof. Mike Althaus
  7. Zahnow, Fynn. BSc Thesis. Investigating Epithelial Sodium Channel Diversity in Terrestrial Artiodactyla: An Integrative Approach using Genomic Databases with Experimental Validation in Ovis aries. Supervisor: Prof. Mike Althaus
  8. Hollenbeck, Jana C. MSc Thesis. Ketone Body Metabolism in Retinal Müller Cells. Supervisor: Prof. Jörn Oliver Sass
  9. Hintzen, Julia. BSc Thesis. Ketone metabolism in Naegleria lovaniensis, a model organism for the “brain-eating” amoeba. Supervisor: Prof. Jörn Oliver Sass
  10. Ahmeti, Yllka. BSc Thesis. Analysis of the Activity of the SCOT Isoenzyme Encoded by the OXCT2 Gene.Supervisor: Prof. Jörn Oliver Sass
  11. Ratrianto, Betari Qalhata. BSc Thesis. A Caenorhabditis elegans Mutant as a Potential Invertebrate Animal Model for Human 3-Hydroxy-3-Methylglutaryl Coenzyme A Deficiency. Supervisor: Prof. Jörn Oliver Sass
  12. Schlimgen, Fabian. BSc Thesis. Enzyme Kinetics and Long-Term Enzyme Stability of Human Aminoacylase 3. Supervisor: Prof. Jörn Oliver Sass
  13. Oswald-Hennemann, Jana Naomi. BSc Thesis. Enzymes of ketone body metabolism in patients with 3-hydroxy-3-methylglutaryl-coenzyme A deficiency and in HepG2 cells. Supervisor: Prof. Jörn Oliver Sass
  14. Silva Faria, Claudia. BSc Thesis. Molecular Defects underlying 3-hydroxyisobutyric Aciduria in Humans and Caenorhabditis elegans. Supervisor: Prof. Jörn Oliver Sass
  15. Bruns, Annika Marie. BSc Thesis. Studies of BDH1 Sequence Variants: Searching for Deficiency of Human 3-Hydroyxy-n-Butyrate Dehydrogenase. Supervisor: Prof. Jörn Oliver Sass
2022
  1. Schulke, Daniel. Dr. rer. nat. Amino acid N-acyltransferases in Human Metabolism. Supervisors: Prof. Jörn Oliver Sass, Prof. Michael Gütschow (Universität Bonn)

  2. Arslan, Rula. MSc Thesis. An Improved Enzyme Activity Test for Aspartoacylase in Laboratory

    Diagnostics of Canavan Disease. Supervisor: Prof. Jörn Oliver Sass
  3. Enoruwa, David. MSc Thesis. Overexpression, Partial Purification and Partial Characterization of Human N-Acetyl-aspartylglutamate Synthetase II. Supervisor: Prof. Jörn Oliver Sass

  4. Sarah Heß. PhD Thesis. Optimierung von STR-Profilen aus telogenen Einzelhaaren. Supervisor: Prof Richard Jäger
  5. Fabian May. BSc Thesis. Development of an automated electrophysiology protocol to study proteolytic activation of epithelial sodium channels. Supervisor: Prof. Mike Althaus

  6. Philipp Vorrat. BSc Thesis. Development of an automated electrophysiology protocol to study sodium self-inhibition in epithelial sodium channels. Supervisor: Prof. Mike Althaus

  7. Yassmin Mohamed. MSc Thesis. Analysis of Pseudogenization of ENaC coding Genes in Marine Mammals and Potential Contribution of Delta ENaC in Sodium Taste. Supervisor: Prof. Mike Althaus

  8. Victoria Malcherek. BSc Thesis. Development of a Manual Gene Search Strategy to Search for δ-ENaC in Lungfish Species. Supervisor: Prof. Mike Althaus

  9. Rene Yufenyuy Lawong. MSc Thesis. Isoform-specific-regulation of the mammalian Epithelial sodium channel (ENaC) in the αßy- and dßy-subunit arrangements. Supervisor: Prof. Mike Althaus

  10. Rafael Adrian Vazquez Alor. MSc Thesis. Sodium homeostasis in the sea lamprey. Supervisor: Prof. Mike Althaus

2021

  1. Sara-Sophie Poethe. Bachelor Thesis. Validation of a method using Illumina Next Generation Sequencing for forensic DNA typing. Supervisor: Prof Richard Jäger
  2. Sandra Eickert. Bachelor Thesis. Identification of sequence variants of the human OXCT2 gene by Next Generation Sequencing (NGS) of DNA.  Supervisors: Prof Jörn Oliver Sass, Prof Richard Jäger
  3. Mishell Montserratt García Villamarín. Bachelor Thesis. Characterization of High and Low Biomass Environmental Samples by 16S and ITS Targeted Amplicon Sequencing. Supervisor: Prof Martin Sieber
  4. Richard Tillmann. Bachelor Thesis. Establishment of Long-Range PCR assays for Next Generation Sequencing based Analysis of Parkinson Disease related Human Solute Carrier Genes. Supervisor: Prof Richard Jäger
  5. Susanne Kurz. BSc Thesis. Glutarylation in Glutaric Aciduria Type 1. Supervisor: Prof Jörn Oliver Sass
  6. Chantal Schmitt. BSc Thesis. Exploration of Enzymes involved in Ketone Body Metabolism. Supervisor: Prof Jörn Oliver Sass

2020

  1. Jasmin Ewert. Bachelor Thesis. Establishment of a Long-Range PCR based NGS Assay for High Throughput Sequencing of the Human Parkinson’s Disease associated Transporter Genes SLC6A3 and SLC22A3.  Supervisors: Prof. Dr. Richard Jäger, Prof. Dr. Walter Witke.
  2. Arthur Cleal. Bachelor Thesis. Quantitative PCR based analysis of DNA degradation. Supervisor: Prof. Dr. Richard Jäger.
  3. Rahinat Muhammad. Bachelor Thesis. The exploration of long-range polymerase chain reaction and next-generation sequencing procedures for the detection of mutations in the MPV17 gene. Supervisors: Prof. Dr. Hans Weiher.
  4. Anna Mona Rosendahl. Bachelor Thesis. Optimization of Loci Balance for Short Tandem Repeat Analysis by Next Generation Sequencing. Supervisor: Prof. Dr. Richard Jäger.
  5. Yuleisy Lucrecia Whilby Hall. Bachelor Thesis. Development and Realisation of a Clinical Trial Regarding the Effect of Herbal Mouthwash with Antibacterial Properties for the Oral Microbiome of Healthy Subjects. Supervisor: Prof. Martin Sieber.
  6. Glenn MG Theunissen. PhD Thesis. DNA profiling of single sperm cells and single skin flakes using micromanipulation and whole genome amplification. Supervisor: Prof. Dr. Richard Jäger.
  7. Nina Wetzig. Bachelor Thesis. Taxonomiebasierte statistische Mikrobiomanalyse auf Basis von NGS Daten. Supervisor: Prof. Dr. Ralf Thiele.
  8. Sonia Aktar. MSc Thesis. Bi-allelic co-expression of selected sequence variants in the ASPA gene for the study of compound heterozygosity. Supervisor: Prof. Jörn Oliver Sass
  9. Annika Brimmers. BSc Thesis. Research on human ketone body utilization: expressing and characterizing isoforms and mutants of succinyl-coenzyme A : 3-oxoacid coenzyme A transferase. Supervisor: Prof. Jörn Oliver Sass
  10. Jana Caroline Hollenbeck. BSc Thesis. Aminoacylase 1 in Huntington disease. Supervisor: Prof. Jörn Oliver Sass
  11. Enise Kumas. BSc Thesis. Assessment of 3-hydroxy-2-methylbutyryl-coenzyme A dehydrogenase in human cells. Supervisor: Prof. Jörn Oliver Sass
  12. Viktoria Pasareva. MSc Thesis. Overexpression, Purification and Characterization of the Endoprotease Activity and Kinetics of Human Aminoacylase 3. Supervisor: Prof. Jörn Oliver Sass
  13. Imke von Stülpnagel. BSc Thesis. Partial Characterisation of recombinant human Glycine N-acyltransferase-like protein 2 and the influence of sequence variation on enzyme activity. Supervisor: Prof. Jörn Oliver Sass
  14. Tamara Wied. BSc Thesis. Compound Heterozygosity in Aspartoacylase Deficiency. Supervisor: Prof. Jörn Oliver Sass

2019

  1. Maria del Mar Boronat. Bachelor Thesis. Relationship between DNA degradation and post-mortem interval. Supervisor: Prof. Dr. Richard Jäger.
  2. Adesanoye Neville Olabode. Meta-analysis of microbiome clinical trials and microbial analysis of skin and soil samples. Supervisor: Prof Martin Sieber.
  3. Simone Janik. Bachelor Thesis. Eine statistische Analyse von Mikrobiomdaten aus dem Next Generation Sequencing. Supervisor: Prof. Dr. Ralf Thiele.
  4. Sebastian Ginzel. PhD Thesis. Enabling Versatile And Comprehensive Analysis Of Genomic Variant DataSupervisor: Prof. Dr. Ralf Thiele.
  5. Rebecca Engler. BSc Thesis. Enzyme activity of sulfite oxidase in human cells. Supervisor: Prof. Jörn Oliver Sass
  6. Mhd Aghyad Al Kabbani. MSc Thesis. Purification and Characterization of Recombinant Human Acylpeptide Hydrolase. Supervisor: Prof. Jörn Oliver Sass
  7. Niloufar Mosaddeghzadeh. MSc Thesis. Assessment of Read-through drugs in Canavan disease. Supervisor: Prof. Jörn Oliver Sass

2018

  1. Despina Yohanna Tsortouktzidis. Characterization of Acylpeptide  hydrolase (APEH) sequence variants and their potential impact on pharmacogenetics. Supervisor: Prof. Jörn Oliver Sass