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Fachbereich Angewandte Naturwissenschaften

Oliver Rauh

Dr. Oliver Rauh

Wissenschaftlicher Mitarbeiter

Gliederung

Fachbereich Angewandte Naturwissenschaften

Forschungsfelder

  • Ion Channels, Electrophysiology, Kinetic Modelling, Molecular Biology

Standort

Rheinbach

Raum

E104

Adresse

Von-Liebig-Straße 20

53359 Rheinbach

Telefon

+4922418659778

Profil

Unravelling of structure/function correlates in ENaC channels

Research Methods

  • Manual and Automated Whole-Cell Patch-Clamp
  • Planar-Lipid Bilayers
  • (Confocal) Fluorescence Microscopy
  • Kinetic Modelling and Analysis of Ion Channel Function
  • Mammalian Cell Culture, E. coli based Growth and Ion Flux Measurements, Cloning

Lebenslauf

11/2014-5/2018 Doctorate in Biophysics in the High Resolution Ion Channel Dynamics Group of Dr. Indra Schröder, TU Darmstadt, Germany

1/2017-6/2017 Exchange researcher at the Columbia University Medical Center (New York City, NY) in the Molecular Physiology Group of Ph.D. Henry Colecraft

6/2018-8/2023 Postdoctoral researcher in the Membrane Biophysics Group of Prof. Dr. Gerhard Thiel, TU Darmstadt, Germany

9/2023-7/2024 Postdoctoral researcher in the Neurophysiology and Neurosensory Systems Group of Prof. Dr. Bodo Laube, TU Darmstadt, Germany

8/2024-present Postdoctoral researcher in the Physiology Group of Prof. Dr. Mike Althaus, HBRS Rheinbach

Mitgliedschaften

German Biophysical Society (Deutsche Gesellschaft für Biophysik)

Publikationen

Dr. Oliver Rauh

2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2015 | 2014

2024

Tobias Schulze, Timon Sprave, Carolin Groebe, Jan Krumbach, Magnus Behringer, Kay Hamacher, Gerhard Thiel, Christian Grimm, Oliver Rauh: Proton selective conductance and gating of lysosomal cation channel TMEM175.
doi:10.1101/2024.11.01.621492 BibTeX | RIS

Noel Tewes, Beatrice Kubitzki, Flandrit Bytyqi, Nikola Metko, Sebastian Mach, Gerhard Thiel, Oliver Rauh: Mutation in pore-helix modulates interplay between filter gate and Ba2+ block in a Kcv channel pore.
doi:10.1085/jgp.202313514 PMID BibTeX | RIS

Klara Eisenhauer, Wadim Weber, Philipp Kemp, Carolin Gebhardt, Marwan Kaufmann, Noel Tewes, Hanna Zhdanova, Alesia Tietze, Oliver Rauh, Viktor Stein: Scaling the Functional Nanopore (FuN) Screen: Systematic Evaluation of Self-Assembling Membrane Peptides and Extension with a K+-Responsive Fluorescent Protein Sensor.
doi:10.1021/acssynbio.3c00671 PMID BibTeX | RIS

2023

Anja J. Engel, Steffen Paech, Markus Langhans, James L. van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh: Combination of hydrophobicity and codon usage bias determines sorting of model K+ channel protein to either mitochondria or endoplasmic reticulum.
doi:10.1111/tra.12915 PMID BibTeX | RIS

Jan H. Krumbach, Daniel Bauer, Atiyeh Sadat Sharifzadeh, Andrea Saponaro, Rene Lautenschläger, Kristina Lange, Oliver Rauh, Dario DiFrancesco, Anna Moroni, Gerhard Thiel, Kay Hamacher: Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block.
doi:10.1085/jgp.202313364 PMID BibTeX | RIS

2021

Timo Smit, Esther Schickel, Omid Azimzadeh, Christine von Toerne, Oliver Rauh, Sylvia Ritter, Marco Durante, Insa S. Schroeder: A Human 3D Cardiomyocyte Risk Model to Study the Cardiotoxic Influence of X-rays and Other Noxae in Adults.
doi:10.3390/cells10102608 PMID BibTeX | RIS

Stefano Conti Nibali, Maria Carmela Di Rosa, Oliver Rauh, Gerhard Thiel, Simona Reina, Vito de Pinto: Cell-free electrophysiology of human VDACs incorporated into nanodiscs: An improved method.
doi:10.1016/j.bpr.2021.100002 PMID BibTeX | RIS

Anja J. Engel, Marina Kithil, Markus Langhans, Oliver Rauh, Matea Cartolano, James L. van Etten, Anna Moroni, Gerhard Thiel: Codon Bias Can Determine Sorting of a Potassium Channel Protein.
doi:10.3390/cells10051128 PMID BibTeX | RIS

Laura-Marie Winterstein, Kerri Kukovetz, Ulf-Peter Hansen, Indra Schroeder, James L. van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh: Distinct lipid bilayer compositions have general and protein-specific effects on K+ channel function.
doi:10.1085/jgp.202012731 PMID BibTeX | RIS

2020

Kerri Kukovetz, Brigitte Hertel, Christopher R. Schvarcz, Andrea Saponaro, Mirja Manthey, Ulrike Burk, Timo Greiner, Grieg F. Steward, James L. van Etten, Anna Moroni, Gerhard Thiel, Oliver Rauh: A Functional K+ Channel from Tetraselmis Virus 1, a Member of the Mimiviridae.
doi:10.3390/v12101107 PMID BibTeX | RIS

Carter R. Murry, Irina V. Agarkova, Jayadri S. Ghosh, Fiona C. Fitzgerald, Roger M. Carlson, Brigitte Hertel, Kerri Kukovetz, Oliver Rauh, Gerhard Thiel, James L. van Etten: Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae.
doi:10.3390/v12060678 PMID BibTeX | RIS

2019

Denise Eckert, Tobias Schulze, Julian Stahl, Oliver Rauh, James L. van Etten, Brigitte Hertel, Indra Schroeder, Anna Moroni, Gerhard Thiel: A small viral potassium ion channel with an inherent inward rectification.
doi:10.1080/19336950.2019.1605813 PMID BibTeX | RIS

2018

O. Rauh, U. P. Hansen, D. D. Scheub, G. Thiel, I. Schroeder: Site-specific ion occupation in the selectivity filter causes voltage-dependent gating in a viral K+ channel.
doi:10.1038/s41598-018-28751-w PMID BibTeX | RIS

Laura-Marie Winterstein, Kerri Kukovetz, Oliver Rauh, Daniel L. Turman, Christian Braun, Anna Moroni, Indra Schroeder, Gerhard Thiel: Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers.
doi:10.1085/jgp.201711904 PMID BibTeX | RIS

2017

Oliver Rauh, Ulf-Peter Hansen, Sebastian Mach, Andreas J. W. Hartel, Kenneth L. Shepard, Gerhard Thiel, Indra Schroeder: Extended beta distributions open the access to fast gating in bilayer experiments-assigning the voltage-dependent gating to the selectivity filter.
doi:10.1002/1873-3468.12898 PMID BibTeX | RIS

Andrea Saponaro, Alessandro Porro, Antonio Chaves-Sanjuan, Marco Nardini, Oliver Rauh, Gerhard Thiel, Anna Moroni: Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
doi:10.1105/tpc.17.00375 PMID BibTeX | RIS

Oliver Rauh, Martin Urban, Leonhard M. Henkes, Tobias Winterstein, Timo Greiner, James L. van Etten, Anna Moroni, Stefan M. Kast, Gerhard Thiel, Indra Schroeder: Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in K+ Channels.
doi:10.1021/jacs.7b01158 PMID BibTeX | RIS

Patrick Voos, Mehtap Yazar, René Lautenschläger, Oliver Rauh, Anna Moroni, Gerhard Thiel: The small neurotoxin apamin blocks not only small conductance Ca2+ activated K+ channels (SK type) but also the voltage dependent Kv1.3 channel.
doi:10.1007/s00249-016-1196-0 PMID BibTeX | RIS

2015

Ulf-Peter Hansen, Oliver Rauh, Indra Schroeder: A simple recipe for setting up the flux equations of cyclic and linear reaction schemes of ion transport with a high number of states: The arrow scheme.
doi:10.1080/19336950.2015.1120391 PMID BibTeX | RIS

2014

Fenja Siotto, Corinna Martin, Oliver Rauh, James L. van Etten, Indra Schroeder, Anna Moroni, Gerhard Thiel: Viruses infecting marine picoplancton encode functional potassium ion channels.
doi:10.1016/j.virol.2014.05.002 PMID BibTeX | RIS