Analysis platform for molecular mechanisms and cellular functions

With the "Analysis Platform for Molecular Mechanisms and Cellular Functions" consisting of four components, three bioscientists are striving to significantly expand the biomedical analysis possibilities at the Hochschule Bonn-Rhein-Sieg (H-BRS).

This project is funded by a large-scale equipment initiative of the German Research Foundation. The already well-established research of the Institute for Functional Gene Analysis (IFGA) in the field of nucleic acid analysis, is now to be further developed by establishing additional functional investigations.

• A binding analysis device based on microscaled thermophoresis contributes an innovative approach to the characterisation of interactions involving proteins.
• A multi-mode detection device for UV/Vis, fluorescence and luminescence allows, among other things, a variety of enzyme activity tests and imaging investigations.
• An automated patch clamp system and a system for solid-supported membrane (SSM)-based electrophysiology for high-resolution transporter studies provide the equipment basis for expanding research into inborn errors of metabolism, channelopathies and drug design.