Claudio Neidhöfer, Derick Lekealem Nkwetta, Bangsi Rose Fuen, Njodzeka Flora Yenban, Nancielle Mbiatong, Gordon Takop Nchanji, Patricia Korir, Nina Wetzig, Martin Sieber, Ralf Thiele, Marijo Parcina, Ute Klarmann-Schulz, Achim Hoerauf, Samuel Wanji, Manuel Ritter: Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria. In: Scientific Reports, 13(1), 13785, 2023
PDF Download (CC BY 4.0) doi:10.1038/s41598-023-40765-7 PMID urn:nbn:de:hbz:1044-opus-75099 BibTeX | RIS

Claudio Neidhöfer, Maria Bagniceva, Nina Wetzig, Martin A. Sieber, Ralf Thiele, Marijo Parčina: Pragmatic Considerations When Extracting DNA for Metagenomics Analyses of Clinical Samples. In: International Journal of Molecular Sciences, 24(14), 11262, 2023
PDF Download (CC BY 4.0) doi:10.3390/ijms241411262 urn:nbn:de:hbz:1044-opus-73988 PMID BibTeX | RIS

Mateja Condic, Claudio Neidhöfer, Damian J. Ralser, Nina Wetzig, Ralf Thiele, Martin Sieber, Lucia A. Otten, Leonie K. Warwas, Achim Hoerauf, Alexander Mustea, Marijo Parčina: Analysis of the cervical microbiome in women from the German national cervical cancer screening program. In: Journal of Cancer Research and Clinical Oncology, 149(9), 2023, S. 6489-6500
PDF Download (CC BY 4.0) doi:10.1007/s00432-023-04599-0 PMID urn:nbn:de:hbz:1044-opus-66298 BibTeX | RIS

Sara-Sophie Poethe, Julia Holtel, Jan-Philip Biermann, Trine Riemer, Melanie Grabmüller, Burkhard Madea, Ralf Thiele, Richard Jäger: Cost-Effective Next Generation Sequencing-Based STR Typing with Improved Analysis of Minor, Degraded and Inhibitor-Containing DNA Samples. In: International Journal of Molecular Sciences, 24(4), 3382, 2023
PDF Download (CC BY 4.0) doi:10.3390/ijms24043382 urn:nbn:de:hbz:1044-opus-66045 PMID BibTeX | RIS

Claudio Neidhöfer, Esther Sib, Al-Harith Benhsain, Christina Mutschnik-Raab, Anna Schwabe, Alexander Wollkopf, Nina Wetzig, Martin A. Sieber, Ralf Thiele, Manuel Döhla, Steffen Engelhart, Nico T. Mutters, Marijo Parčina: Examining Different Analysis Protocols Targeting Hospital Sanitary Facility Microbiomes. In: Microorganisms, 11(1), 185, 2023
PDF Download (CC BY 4.0) doi:10.3390/microorganisms11010185 urn:nbn:de:hbz:1044-opus-65910 PMID BibTeX | RIS

Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Kloetgen, Michael Gombert, Ute Fischer, Daniel Hein, Salih Demir, Martin Stanulla, Martin Schrappe, Udo Zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Beat Bornhauser, Jean-Pierre Bourquin, Stefan Krause, Juergen Enczmann, Lüder Hinrich Meyer, Cornelia Eckert, Arndt Borkhardt, Roland Meisel: Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets. In: Blood Advances, 3(20), 2019, S. 3143-3156
doi:10.1182/bloodadvances.2019000051 PMID BibTeX | RIS

Sarah Aurora Heß, Jan-Philip Biermann, Melanie Grabmüller, Burkhard Madea, Ralf Thiele, Richard Jäger: Evaluation of STR profiles of single telogen hairs using probabilistic methods. In: Forensic Science International: Genetics Supplement Series, 7(1), 2019, S. 454-456
doi:10.1016/j.fsigss.2019.10.049 BibTeX | RIS

David Stahl, Andrew J. Gentles, Ralf Thiele, Ines Gütgemann: Prognostic profiling of the immune cell microenvironment in Ewing´s Sarcoma Family of Tumors. In: OncoImmunology, 8(12), e1674113, 2019
doi:10.1080/2162402x.2019.1674113 PMID BibTeX | RIS

D. Stahl, R. Thiele, A. J. Gentles, S. Schönberger, G. Kristiansen, I. Gütgemann: Prognostic profiling of the immune cell microenvironment in Ewing sarcoma/PNET. In: Der Pathologe, 40(Suppl 2), 2019, S. S105-S106
URL BibTeX | RIS

Jessica I. Hoell, Sebastian Ginzel, Michaela Kuhlen, Andreas Klötgen, Michael Gombert, Ute Fischer, Daniel Schäfer, Martin Stanulla, Martin Schrappe, Udo zur Stadt, Peter Bader, Florian Babor, Friedhelm Schuster, Brigitte Strahm, Julia Alten, Anja Moericke, Gabriele Escherich, Arend von Stackelberg, Ralf Thiele, Alice C. McHardy, Christina Peters, Cornelia Eckert, Arndt Borkhardt, Roland Meisel: Whole-Exome-Sequencing identifiziert hohe Plastizität, Selektionsdruck und „druggable targets“ in Leukämiezellen pädiatrischer ALL Rezidive nach allogener Stammzelltransplantation. In: Monatsschrift Kinderheilkunde, 166(7), 2018, S. 648
URL BibTeX | RIS

Maria Joosten, Sebastian Ginzel, Christian Blex, Dmitri Schmidt, Michael Gombert, Cai Chen, René Martin Linka, Olivia Gräbner, Anika Hain, Burkhard Hirsch, Anke Sommerfeld, Anke Seegebarth, Uschi Gruber, Corinna Maneck, Langhui Zhang, Katharina Stenin, Henrik Dieks, Michael Sefkow, Carsten Münk, Claudia D. Baldus, Ralf Thiele, Arndt Borkhardt, Michael Hummel, Hubert Köster, Ute Fischer, Mathias Dreger, Volkhard Seitz: A novel approach to detect resistance mechanisms reveals FGR as a factor mediating HDAC inhibitor SAHA resistance in B-cell lymphoma. In: Molecular Oncology, 10(8), 2016, S. 1232-1244
doi:10.1016/j.molonc.2016.06.001 PMID BibTeX | RIS

Alberto Martin-Lorenzo, Julia Hauer, Carolina Vicente-Duenas, Franziska Auer, Ines Gonzalez-Herrero, Idoia Garcia-Ramirez, Sebastian Ginzel, Ralf Thiele, Stefan N. Constantinescu, Christoph Bartenhagen, Martin Dugas, Michael Gombert, Daniel Schafer, Oscar Blanco, Andrea Mayado, Alberto Orfao, Diego Alonso-Lopez, Javier de Las Rivas, Cesar Cobaleda, Maria Begona Garcia-Cenador, Francisco Javier Garcia-Criado, Isidro Sanchez-Garcia, Arndt Borkhardt: Infection Exposure Is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility. In: Cancer Discovery, 5(12), 2015, S. 1328-1343
doi:10.1158/2159-8290.CD-15-0892 PMID BibTeX | RIS

Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Hönscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer: Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease. In: Haematologica, 100(9), 2015, S. 1189-1198
doi:10.3324/haematol.2014.114967 PMID BibTeX | RIS

Ute Fischer, Michael Forster, Anna Rinaldi, Thomas Risch, Stéphanie Sungalee, Hans-Jörg Warnatz, Beat Bornhauser, Michael Gombert, Christina Kratsch, Adrian M. Stütz, Marc Sultan, Joelle Tchinda, Catherine L. Worth, Vyacheslav Amstislavskiy, Nandini Badarinarayan, André Baruchel, Thies Bartram, Giuseppe Basso, Cengiz Canpolat, Gunnar Cario, Hélène Cavé, Dardane Dakaj, Mauro Delorenzi, Maria Pamela Dobay, Cornelia Eckert, Eva Ellinghaus, Sabrina Eugster, Viktoras Frismantas, Sebastian Ginzel, Oskar A. Haas, Olaf Heidenreich, Georg Hemmrich-Stanisak, Kebria Hezaveh, Jessica I. Höll, Sabine Hornhardt, Peter Husemann, Priyadarshini Kachroo, Christian P. Kratz, Geertruy Te Kronnie, Blerim Marovca, Felix Niggli, Alice C. McHardy, Anthony V. Moorman, Renate Panzer-Grümayer, Britt S. Petersen, Benjamin Raeder, Meryem Ralser, Philip Rosenstiel, Daniel Schäfer, Martin Schrappe, Stefan Schreiber, Moritz Schütte, Björn Stade, Ralf Thiele, Nicolas von der Weid, Ajay Vora, Marketa Zaliova, Langhui Zhang, Thomas Zichner, Martin Zimmermann, Hans Lehrach, Arndt Borkhardt, Jean-Pierre Bourquin, Andre Franke, Jan O. Korbel, Martin Stanulla, Marie-Laure Yaspo: Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. In: Nature Genetics, 47(9), 2015, S. 1020-1029
doi:10.1038/ng.3362 PMID URL BibTeX | RIS

Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Silja Röttgers, Jutta Bradtke, Andrea Teigler-Schlegel, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Peter Husemann, Pina F.I. Krell, Arndt Borkhardt, Martin Dugas, Jianda Hu, Ute Fischer: Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients. In: Leukemia Research, 39(9), 2015, S. 990-1001
doi:10.1016/j.leukres.2015.06.005 PMID BibTeX | RIS

Schafiq Nabhani, Sebastian Ginzel, Hagit Miskin, Shoshana Revel-Vilk, Dan Harlev, Bernhard Fleckenstein, Andrea Höhnscheid, Prasad T. Oommen, Michaela Kuhlen, Ralf Thiele, Hans-Jürgen Laws, Arndt Borkhardt, Polina Stepensky, Ute Fischer: Dysregulation of IL12 Signaling As a Novel Cause of an Autoimmune Lymphoproliferative like Syndrome. In: Blood, 124(21), 1420, 2014
doi:10.1182/blood.v124.21.1420.1420 BibTeX | RIS

J. I. Hoell, M. Gombert, S. Ginzel, S. Loth, P. Landgraf, V. Käfer, M. Streiter, A. Prokop, M. Weiss, R. Thiele, A. Borkhardt: Constitutional Mismatch Repair-deficiency and Whole-exome Sequencing as the Means of the Rapid Detection of the Causative MSH6 Defect. In: Klinische Pädiatrie, 226(06/07), 2014, S. 357-361
doi:10.1055/s-0034-1389905 PMID BibTeX | RIS

Y. Linka, S. Ginzel, M. Krüger, A. Novosel, M. Gombert, E. Kremmer, J. Harbott, R. Thiele, A. Borkhardt, P. Landgraf: The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods. In: Blood Cancer Journal, Vol.3, e151, 2013
PDF Download (CC BY-NC-SA 3.0) doi:10.1038/bcj.2013.48 PMID urn:nbn:de:hbz:1044-opus-10394 BibTeX | RIS

Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Andrea Teigler-Schlegel, Jutta Bradtke, Silja Roettgers, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Martin Dugas, Jianda Hu, Arndt Borkhardt, Ute Fischer: Chromothripsis-Mediated Structural Variations and Clonal Evolution In Recurrent Childhood High Hyperdiploid Acute Lymphoblastic Leukemia. In: Blood, 122(21), 233, 2013
doi:10.1182/blood.v122.21.233.233 BibTeX | RIS

Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Silja Roettgers, Jutta Bradtke, Andrea Teigler-Schlegel, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Ute Fischer, Martin Dugas, Jianda Hu, Arndt Borkhardt: Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia. In: Genes, Chromosomes & Cancer, 52(6), 2013, S. 564-579
doi:10.1002/gcc.22054 PMID BibTeX | RIS

Vera Okpanyi, Christoph Bartenhagen, Michael Gombert, Sebastian Ginzel, Pina Fanny Ida Krell, Peter Husemann, Cai Chen, Vera Binder, Jutta Bradtke, Andrea Teigler-Schlegel, Silja Roettgers, Jochen Harbott, Martin Stanulla, Cornelia Eckert, Ralf Thiele, Martin Dugas, Arndt Borkhardt, Ute Fischer: Novel Genomic Structural Variations in Relapsed Childhood ETV6/RUNX1 (TEL/AML1) Acute Lymphoblastic Leukemias Identified by Next Generation Sequencing. In: Blood, 120(21), 2012, S. 518
doi:10.1182/blood.V120.21.518.518 BibTeX | RIS

Robert Pesch, Artem Lysenko, Matthew Hindle, Keywan Hassani-Pak, Ralf Thiele, Christopher Rawlings, Jacob Köhler, Jan Taubert: Graph-based sequence annotation using a data integration approach. In: Journal of Integrative Bioinformatics, 5(2), 2008, S. 58-72
PDF Download (CC BY-NC-ND 3.0) doi:10.2390/biecoll-jib-2008-94 PMID doi:10.1515/jib-2008-94 urn:nbn:de:hbz:1044-opus-5283 BibTeX | RIS

Ralf Thiele, Ralf Zimmer, Thomas Lengauer: Protein threading by recursive dynamic programming. In: Journal of Molecular Biology, 290(3), 1999, S. 757-779
doi:10.1006/jmbi.1999.2893 PMID BibTeX | RIS

Ralf Zimmer, Marko Wöhler, Ralf Thiele: New scoring schemes for protein fold recognition based on Voronoi contacts. In: Bioinformatics, 14(3), 1998, S. 295-308
doi:10.1093/bioinformatics/14.3.295 PMID BibTeX | RIS

Ralf Zimmer, Ralf Thiele: Fast protein fold recognition and accurate sequence-structure alignment. In: Hofestädt, Lengauer et al. (Eds.): German Conference on Bioinformatics, GCB'96. Leipzig, Germany September 30 - October 2, 1996. Lecture Notes in Computer Science (LNCS), volume 1278, 1997, S. 137-146
doi:10.1007/BFb0033212 BibTeX | RIS

T. Lengauer, R. Thiele, R. Zimmer: Modellierung von Proteinstrukturen. In: Der GMD-Spiegel, 1996, S. 14-18
BibTeX | RIS

Ralf Thiele, Ralf Zimmer, Thomas Lengauer: Recursive Dynamic Programming for Adaptive Sequence and Structure Alignment. In: Proceedings of the Third International Conference on Intelligent Systems for Molecular Biology. Cambridge, United Kingdom, July 16-19, 1995, 1995, S. 384-392
PMID BibTeX | RIS

H. Schmidt, D. Theune, R. Thiele, T. Lengauer: EMC-driven midway routing on PCBs. In: Proceedings of the 1995 European conference on Design and Test, ED&TC 1995. Paris, France, 6-9 March 1995, 1995, S. 486-491
doi:10.1109/EDTC.1995.470357 BibTeX | RIS

H. Mevissen, R. Thiele, R. Zimmer, T. Lengauer: The ToPLign Software Environment - Toolbox for Preotein Alignment. In: Bioinformatik-Konferenz, Jena, 1994, 1994
BibTeX | RIS

D. Theune, R. Thiele, W. John, T. Lengauer: Robust methods for EMC-driven routing. In: IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, 13(11), 1994, S. 1366-1378
doi:10.1109/43.329265 BibTeX | RIS

W. John, D. Theune, R. Thiele: Layout design for printed-circuit boards under EMC-constraints. In: Electromagnetic Compatibility, Zürich 1993, 1993, S. 225-232
BibTeX | RIS

Dirk Theune, Ralf Thiele, Thomas Lengauer, Anja Feldmann: HERO: Hierarchical EMC-constrained routing. In: 1992 IEEE/ACM International Conference on Computer-Aided Design, ICCAD 1992. Santa Clara, CA, USA, November 8-12, 1992. Digest of Technical Papers, 1992, S. 468-472
doi:10.1109/ICCAD.1992.279326 BibTeX | RIS