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Graduate Institute

Sarah Shoushrah

PhD Student/ M.Sc. Diagnostic Molecular Biology & Human Genetics


Graduate Institute




Von-Liebig-Straße 20

53359 Rheinbach


PhD Project

Induced mesenchymal stem cells and their secreted factors as a new therapeutic approach for bone grafts

What can't be cured must be endured, however, researchers are trying to change this fact and are aiming to improve and provide new treatment options for a variety of different diseases. One of these diseases are large, so-called “critical size” bone injuries, which cannot heal in the life span of an individual without extensive interventions. One approach to change this is using mesenchymal stem cells (MSCs) which have shown a great potential for treatment of such conditions. They can differentiate into bone cells and release therapeutic factors in addition. Under specific circumstances however, they can be limited in quantity and they cannot retain their abilities during prolonged lab culture. Recently, the discovery of induced pluripotent stem cells (iPSCs), for which the Nobel Prize was given in 2012, offered a new approach. These cells can be generated into mesenchymal stem cells (iMSCs) in the lab on-demand and are thus providing a possible alternative technique. iMSCs have similarities to MSCs but still little is known about them. In this project, Sarah Shoushrah will discern how similar and effective iMSCs are in comparison to MSCs for future applications in bone repair.

Supervisor at H-BRS: Prof. Dr. Edda Tobiasch
Supervisor at Partner University Rheinische Friedrich-Wilhelms-Universität Bonn: Prof. Dr. med. Werner Götz


2021 | 2019


Sarah Hani Shoushrah, Janis Lisa Transfeld, Christian Horst Tonk, Dominik Büchner, Steffen Witzleben, Martin A. Sieber, Margit Schulze, Edda Tobiasch: Sinking Our Teeth in Getting Dental Stem Cells to Clinics for Bone Regeneration.
PDF Download (CC BY 4.0) doi:10.3390/ijms22126387 urn:nbn:de:hbz:1044-opus-55476 PMID BibTeX | RIS


Markus Witzler, Dominik Büchner, Sarah Hani Shoushrah, Patrick Babczyk, Juliana Baranova, Steffen Witzleben, Edda Tobiasch, Margit Schulze: Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration.
PDF Download (CC BY 4.0) doi:10.3390/biom9120840 urn:nbn:de:hbz:1044-opus-47024 PMID BibTeX | RIS